Welcome to the Finkelstein Lab

The Finkelstein lab is focused on understanding how our cells are able to stave off genomic instability and avoid premature aging. Our highly interdisciplinary research program combines aspects of single-molecule biophysics, traditional biochemistry and micro-/nano-scale engineering to directly observe the key biochemical steps of DNA maintenance. We address fundamental questions regarding how cells coordinate multi-protein assemblies on DNA, how these biochemical reactions occur on a highly condensed DNA-protein substrate, and how defects in these pathways lead to genomic instability.

DNA curtains: Arrays of surface-tethered DNA molecules assembled at micron-scale chromium barriers.
Micron-scale 3D-printed cell capture devices.
Fluorescent fission yeast cells expressing an RFP proteasome marker.
An optical image of 24 chromium barrier sets (from a total of 792)
that are deposited onto a flowcell.
Merging next-gen sequencing and single-molecule imaging opens up new opportunities for
high-throughput studies of protein-DNA interactions.
A protein (magenta) and a subset of fluorescent DNA sequences (green) on
a regenerated next-generation sequencing chip.
Illustration of a eukaryotic mismatch repair complex scanning DNA for errors.
Watching the replicative lifespan of single fission yeast cells expressing a GFP reporter.
The Fission Yeast Lifespan Microdissector (FYLM), a microfluidic device that captures and
immobilizes hundreds of individual cells for their entire lifespan.

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